Kolhe Lab

Leading the Future of Molecular Diagnostics

The Kolhe Lab is recognized for its expertise in validating emerging technologies for clinical implementation, ensuring their translation into precision oncology practice. Under the leadership of Dr. Kolhe, the lab contributes significantly to the advancement of the field through service in influential consortiums and the publication of high-impact, peer-reviewed research. The lab serves as an NCI-designated site for comprehensive genomic testing in oncology (MATCH), supporting national efforts to expand access to state-of-the-art molecular diagnostics.

Dr. Ravindra Kolhe, MD, PhD, FCAP, has co-founded the Sequencing and Oncological Informatics Academic Team (SEQUOIA), an international consortium of clinical professionals employing TSO 500. He is also a co-founder of the International Consortium for Optical Genome Mapping (ICOGM) centered on engaging the cytogenomics community in the advancement of OGM. He currently serves as the Chair of the Department of Pathology, Edgar R. Pund Distinguished Chair in Pathology, Director of the Georgia Esoteric and Molecular Laboratory, Associate Dean for Translational Research at the Medical College of Georgia, and Associate Director for Genomics at the Georgia Cancer Center.

RESEARCH NEWS

Kolhe Lab postdoctoral fellows, Ashutosh and Vishakha Vashisht, presented three posters at the Association for Molecular Pathology (AMP) Annual Meeting and Exposition in November, 2025. The posters were titled "Clinical Evaluation and Validation of DNBSEQ Sequencing Using a Comprehensive Genomic Panel in Solid Tumors," "Cross-Platform Evaluation of HRD Scoring: Variability, Interpretation, and Clinical Implications of Interactive vs Automated Systems," and "Cost-Effective and Rapid Mutation Profiling in Color Cancer: A Comparative Validation of the iPLEX® HS Colon MALDI-TOF Panel."

Featured publications

Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19

Clinical and molecular assessment of an onco‐immune signature with prognostic significance in patients with colorectal cancerColorectal cancer has a complex tumor microenvironment that also provides a unique opportunity for the molecular classification of these patients. In this study, we have used NanoString technology to...

Infections of the lung: a predictive, preventive and personalized perspective through the lens of evolution, the emergence of SARS-CoV-2 and its pathogenesis - EPMA Journal

Optical Genome Mapping and Single Nucleotide Polymorphism Microarray: An Integrated Approach for Investigating Products of Conception

Clinical Validation and Diagnostic Utility of Optical Genome Mapping in Prenatal Diagnostic Testing

High-Throughput Next-Generation Sequencing Respiratory Viral Panel: A Diagnostic and Epidemiologic Tool for SARS-CoV-2 and Other Viruses

Clinical Validation of a Sensitive Test for Saliva Collected in Healthcare and Community Settings with Pooling Utility for Severe Acute Respiratory Syndrome Coronavirus 2 Mass SurveillanceThe clinical performance of saliva compared with nasopharyngeal swabs (NPSs) has shown conflicting results in healthcare and community settings. In th…

Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma - Scientific Reports

Ethno‐demographic disparities in humoral responses to the COVID‐19 vaccine among healthcare workersJournal of Medical Virology is a clinical virology journal focused on the diagnosis, epidemiology, immunology and pathogenesis of human viral infections & diseases.

Infection and Immune Memory: Variables in Robust Protection by Vaccines Against SARS-CoV-2

Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19

SalivaSTAT: Direct-PCR and Pooling of Saliva Samples Collected in Healthcare and Community Setting for SARS-CoV-2 Mass Surveillance

Clinical validation of a multiplex PCR-based detection assay using saliva or nasopharyngeal samples for SARS-Cov-2, influenza A and B - Scientific Reports

Optical Genome Mapping: Integrating Structural Variations for Precise Homologous Recombination Deficiency Score Calculation

Guideline-Adherent Clinical Validation of a Comprehensive 170-Gene DNA/RNA Panel for Determination of Small Variants, Copy Number Variations, Splice Variants, and Fusions on a Next-Generation Sequencing Platform in the CLIA Setting

Natural Killer Cells and Dendritic Cells: Expanding Clinical Relevance in the Non-Small Cell Lung Cancer (NSCLC) Tumor Microenvironment

Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer

Page updated

Google Sites

Report abuse